New cell therapy aims to tame lupus and scleroderma

NCT ID NCT06434363

First seen Nov 01, 2025 · Last updated Jun 17, 2026 · Updated 32 times

Summary

This study tests a new treatment that uses specially designed immune cells (AD-PluReceptor-NK cells) combined with a drug called tafasitamab and chemotherapy to control autoimmune diseases like systemic sclerosis, lupus, and lupus nephritis. The study has three parts: first checking safety, then finding the best dose, and finally seeing if it helps control the disease. About 47 adults will take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • The University of Texas Health Science Center at Houston

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

The condition(s) this trial relates to.

autoimmune disease Bronchiolitis Obliterans Syndrome graft versus host disease lupus erythematosus lupus nephritis systemic lupus erythematosus systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.