LUPUS

This early-stage study tests a single injection of stem cells from donated umbilical cords in 10 adults with active lupus. The goal is to see if the treatment is safe and can reduce disease activity and improve kidney function. Participants continue their usual medications and ar…

This study tests a new treatment combining specially designed immune cells (AD-PluReceptor NK cells) with a drug called tafasitamab and chemotherapy for people with autoimmune disorders like systemic sclerosis, lupus, and lupus nephritis. The goal is to find a safe dose and see i…

This early-phase study tests whether a new drug called ONTO1 is safe for people with lupus nephritis or systemic lupus erythematosus (SLE). About 61 participants will receive ONTO1 alongside standard lupus treatments like mycophenolate mofetil. The goal is to find the highest saf…

This study is testing a new medicine called BMS-986326 in 44 adults with discoid, subacute cutaneous, or systemic lupus. The main goal is to see if the drug is safe and how it behaves in the body after multiple doses given by IV or injection. Participants will be randomly assigne…

This study tests a new treatment called CART19 for teens and young adults (ages 12-29) with severe lupus that hasn't responded to standard therapies. The treatment uses a patient's own immune cells, modified to target and calm the overactive immune system causing lupus. The goal …

This study tests a type of talk therapy called emotional awareness and expression therapy (EAET) for people with lupus who also have fibromyalgia or chronic widespread pain. The goal is to see if it is safe and can reduce pain and other symptoms. Thirty adults will attend 8 weekl…

This study is creating and testing a program to support brain health in children and teens with lupus. The goal is to see if the program is practical and helpful for improving quality of life. About 60 participants aged 13-18 will take part. The program focuses on reducing sympto…

This study compares two online programs for people with chronic pain: an 8-week cognitive behavioral therapy course and a single 2-hour pain relief skills class. Researchers want to see if the shorter class works as well as the longer one. The study involves 1,650 adults with con…

This early-stage study tests whether baricitinib, a drug already approved for other immune conditions, is safe and tolerable for people with Job syndrome (a rare genetic immune disorder) who also have lupus-like disease or severe eczema. About 20 participants aged 12 and older wi…

This study is creating a large database and biobank from 2200 patients with chronic inflammatory diseases like lupus, multiple sclerosis, and severe asthma. Researchers will track disease activity, quality of life, and treatment responses over time. The goal is to identify new ma…

This study aims to understand the different types of fatigue people experience, especially those with conditions like cancer, lupus, and chronic fatigue syndrome. Researchers will compare fatigued and non-fatigued adults using interviews, questionnaires, physical tests, and optio…

This study is collecting health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to better understand these illnesses and help…

This study collects health information, lifestyle details, and biological samples from up to 100,000 adults aged 18 to 90. The goal is to help researchers better understand conditions like lupus, celiac disease, and kidney disease, and to develop improved tests and treatments. Pa…