Could removing fallopian tubes first prevent ovarian cancer without early menopause?

NCT ID NCT05287451

Recruiting now Prevention Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether removing the fallopian tubes first and delaying ovary removal is as safe as removing both at once to prevent ovarian cancer in women with BRCA or other high-risk gene mutations. About 100 premenopausal women will choose either the new two-step approach or the standard single surgery. Researchers will track how many develop ovarian cancer over time to see if the less invasive option works just as well.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Risk-reducing salpingectomy (removal of fallopian tubes) with delayed oophorectomy (removal of ovaries)
What this could lead to: If successful, this could offer high-risk women a less drastic option to prevent ovarian cancer, potentially preserving ovarian function longer and reducing side effects of early menopause.
What could go wrong: This is an early-stage study with only 100 participants, so results may not apply to everyone. There is a risk that delaying ovary removal could allow cancer to develop in the meantime.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for FALLOPIAN TUBE CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

fallopian tube neoplasm fallopian tube cancer prevention target ovarian cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FALLOPIAN TUBE CANCER OVARIAN CANCER

Contacts and locations

Locations

Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Lyndon Baines Johnson General
RECRUITING

Houston, Texas, 77026, United States
M D Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Mount Sinai Health System
RECRUITING

New York, New York, 10029, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Washington
RECRUITING

Seattle, Washington, 98195, United States
WU St Louis
RECRUITING

St Louis, Missouri, 63130, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.