Can zapping just the growing spots keep cancer in check?

NCT ID NCT06367972

Recruiting now Disease control Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is for people with stage IV cancer that has started to grow in only a few places (oligoprogression). It compares adding local treatments like radiation or surgery to all growing spots versus switching to a new systemic therapy. The goal is to see if this approach can better control the disease. About 400 adults are being recruited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Local Consolidation Therapy (radiation, surgery, ablation, or embolization)
What this could lead to: If it works, this could offer a way to extend the effectiveness of current cancer treatments by targeting only the growing spots, potentially delaying the need for stronger drugs.
What could go wrong: This is an early-to-mid stage trial with 400 participants, so results may not apply to everyone. Local treatments also carry risks like side effects from radiation or procedures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for OLIGOPROGRESSIVE METASTATIC DISEASE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

metastatic malignant neoplasm metastatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OLIGOPROGRESSIVE METASTATIC DISEASE

Contacts and locations

Locations

MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.