Could a tiny dose of radiation tame this lymphoma?

NCT ID NCT05929612

Recruiting now Disease control Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This study tests whether a very low dose of radiation (4 Gy) can control marginal zone lymphoma, a slow-growing blood cancer. Participants first get the low dose, and if needed, a higher dose later. The goal is to see if this approach works with fewer side effects. About 50 adults with early-stage lymphoma are being recruited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ultra-low dose radiation therapy (4 Gy in 2 fractions)
What this could lead to: If successful, this could offer a less intense radiation option for marginal zone lymphoma, potentially reducing side effects while still controlling the disease.
What could go wrong: This is a small, early-phase study (50 participants) and may not show lasting disease control. Some patients may need higher radiation doses, and side effects are still being evaluated.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lymphoma marginal zone lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOMA

Contacts and locations

Locations

MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

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