Blood test could personalize chemo for gut cancer patients
NCT ID NCT05947838
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing whether a simple blood test that measures tumor DNA (ctDNA) can help doctors decide how much chemotherapy to give before surgery for colorectal or appendix cancer that has spread to the abdomen. The goal is to see if the test can identify patients who need stronger chemo versus those who can safely have less. The trial will enroll 48 adults and track side effects to see if this personalized approach is feasible.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- circulating tumor DNA (ctDNA) testing
- What this could lead to
- If successful, this approach could help doctors personalize chemotherapy before surgery, potentially reducing the chance of cancer returning.
- What could go wrong
- This is a small, early feasibility study with only 48 participants, so results may not apply to everyone. The ctDNA test may not accurately predict risk, and side effects from chemotherapy remain possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a new immunotherapy combo shrink Hard-to-Treat tumors?
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