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New drug combo aims to control rare blood cancer in High-Risk patients

NCT ID NCT03383575

Recruiting now Disease control Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a combination of two drugs, azacitidine and enasidenib, in people with a high-risk blood cancer called myelodysplastic syndrome (MDS) that has a specific genetic change (IDH2 mutation). The goal is to see if the drugs can stop cancer growth and improve outcomes. About 63 adults with MDS or related conditions will take part. The treatment is not a cure but aims to control the disease and manage side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia chronic myelomonocytic leukemia myelodysplastic syndrome myelodysplastic syndrome with excess blasts refractory anemia with excess blasts in transformation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA BLASTS 20-30 PERCENT OF BONE MARROW NUCLEATED CELLS CHRONIC MYELOMONOCYTIC LEUKEMIA IDH2 GENE MUTATION MYELODYSPLASTIC SYNDROME WITH EXCESS BLASTS RECURRENT HIGH RISK MYELODYSPLASTIC SYNDROME REFRACTORY HIGH RISK MYELODYSPLASTIC SYNDROME

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Cleveland Clinic Foundation

    ACTIVE_NOT_RECRUITING

    Cleveland, Ohio, 44195, United States

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    ACTIVE_NOT_RECRUITING

    Baltimore, Maryland, 21287, United States

  • M D Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Phone: •••-•••-••••

    Contact