Can radiation reignite cancer control after immunotherapy fails?

NCT ID NCT02710253

Completed Disease control Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This phase II trial tests whether radiation therapy can help control cancer that has spread or grown after immunotherapy. About 230 patients with metastatic or lymphoid cancers will receive targeted radiation to see if it stabilizes the disease or shrinks tumors. The study also monitors side effects to find the best dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: External Beam Radiation Therapy and Stereotactic Body Radiation Therapy
What this could lead to: If it works, this could offer a way to control cancer that has worsened after immunotherapy, potentially slowing disease progression.
What could go wrong: This is a mid-stage trial, so results are not yet proven. Radiation may cause side effects, and not all patients may benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm metastatic malignant neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMATOPOIETIC AND LYMPHOID CELL NEOPLASM METASTATIC MALIGNANT SOLID NEOPLASM

Contacts and locations

Locations

M D Anderson Cancer Center

Houston, Texas, 77030, United States
MD Anderson League City

League City, Texas, 77573, United States
MD Anderson West Houston

Houston, Texas, 77079, United States
MD Anderson in Sugar Land

Sugar Land, Texas, 77478, United States
MD Anderson in The Woodlands

Conroe, Texas, 77384, United States

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