Drug combo aims to stall head and neck Cancer's return
NCT ID NCT00942734
First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time
Summary
This phase 2 trial investigates whether combining two drugs—RAD001 (everolimus) and erlotinib (Tarceva)—can help control recurrent squamous cell carcinoma of the head and neck. The study enrolls adults whose cancer has returned after platinum-based chemotherapy. Participants take both drugs daily in 28-day cycles. The main goal is to see how many patients remain cancer-free or stable after 12 weeks, with safety also monitored.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- RAD001 (everolimus) and erlotinib (Tarceva)
- What this could lead to
- If successful, this combination could offer a new treatment option for patients with recurrent head and neck cancer who have not responded to standard chemotherapy.
- What could go wrong
- This is an early-phase trial with only 49 participants, so results may not apply broadly. The combination may cause side effects and may not improve survival.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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