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Why do Non-Smokers get head and neck cancer? scientists probe tumor DNA

NCT ID NCT00963326

Knowledge-focused Sponsor: Centre Oscar Lambret Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Researchers are studying blood and tumor tissue from people with squamous cell cancer of the larynx, pharynx, or oral cavity who have no history of smoking, heavy drinking, or workplace exposure to substances like asbestos or wood dust. The goal is to learn how DNA changes and biomarkers in these tumors might differ from those in cancers linked to known risk factors. The study enrolls about 30 participants and does not test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If researchers find distinct DNA changes or biomarkers in these tumors, it could point toward new ways to detect or treat head and neck cancers in people without the usual risk factors.
What could go wrong
This is a small laboratory study of 30 people, so any patterns it finds may not hold in larger groups. It does not test a treatment, so it cannot show whether a new therapy works.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

30 people

The number who actually took part.

Started

Mar 2009

Finished

Mar 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with confirmed squamous cell carcinoma of the larynx, pharynx, or oral cavity without risk factors

Ages

15 to 120 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

DISEASE CHARACTERISTICS: * Histologically confirmed squamous cell carcinoma of the larynx, pharynx, or oral cavity * No risk factors of alcohol consumption, smoking, or occupational hazards such as asbestos, hydrocarbons, paints, nickel, stone dust, or wood dust. * Must be a life-time non-smoker, not a former smoker * Measurable disease by RECIST criteria PATIENT CHARACTERISTICS: * WHO performance status 0-1 * No other serious concomitant medical conditions precluding general anesthesia * No psychological, familial, social, or geographical reasons that would preclude follow up PRIOR CONCURRENT THERAPY: * Not specified

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms laryngeal squamous cell carcinoma oral cavity squamous cell carcinoma pharyngeal squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck tongue cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Head and neck cancer

Contacts and locations

Locations

  • CHRU de Lille

    Lille, 59037, France

  • CHU d'Amiens

    Amiens, France

  • CHU de Caen

    Caen, 14033, France

  • CHU de Nîmes

    Nîmes, 30029, France

  • CHU de Rouen

    Rouen, 76031, France

  • Centre Antoine Lacassagne

    Nice, France

  • Centre François Baclesse

    Caen, 14076, France

  • Centre Oscar Lambret

    Lille, 59020, France

  • Hôpital de la Timone

    Marseille, 13385, France

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