Experimental drug targets Notch-Activated cancer before surgery
NCT ID NCT04973683
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase 1 trial tested the drug AL101 in 13 people with a rare salivary gland cancer called adenoid cystic carcinoma that has a specific genetic change (notch activation). Participants received AL101 before their standard surgery to see if it is safe and might help control the cancer. The study focused on side effects and changes in tumor markers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
AL101 (a drug that blocks notch pathway enzymes)
What this could lead to
If it works, this could point toward a new treatment option for adenoid cystic carcinoma with notch activation.
What could go wrong
This is a very early phase 1 trial with only 13 participants, so results may not apply broadly. The drug may cause side effects or fail to shrink tumors.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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M D Anderson Cancer Center
Houston, Texas, 77030, United States