New pill-chemo combo takes on hard-to-treat cancers

NCT ID NCT07667400

First seen Jun 26, 2026 · Last updated Jul 01, 2026 · Updated 4 times

Summary

This study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About 120 adults will take part, receiving the drugs in 3-week cycles for up to 6 cycles.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

SX-682 (a tablet) and docetaxel (a chemotherapy drug given by IV)

What this could lead to

If it works, this combination could offer a new treatment option for people with head/neck or prostate cancers that have spread or come back.

What could go wrong

This is an early-phase trial (Phase I/II) with only 120 participants, so it may not show enough benefit or could have side effects. The drugs may not work for all cancer types studied.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

adenoid cystic carcinoma carcinoma castration-resistant prostate carcinoma head and neck cancer Head and Neck Neoplasms head and neck squamous cell carcinoma hypopharyngeal carcinoma hypopharynx cancer laryngeal carcinoma laryngeal neoplasm metastatic prostate carcinoma nasopharyngeal carcinoma oral cavity squamous cell carcinoma oropharynx squamous cell carcinoma paranasal sinus neoplasm Paranasal Sinus Neoplasms prostate cancer salivary gland cancer salivary gland carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••