New combo therapy aims to boost transplant success in tough leukemia cases
NCT ID NCT03247088
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests adding the targeted drug sorafenib to standard chemotherapy (busulfan and fludarabine) before a donor stem cell transplant in adults with acute myeloid leukemia that has returned or not responded to treatment. The goal is to find the safest dose of sorafenib and see if it helps patients live longer without the cancer coming back. About 74 participants will receive this combination, and researchers will monitor side effects and survival.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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