New drug combo aims to control Hard-to-Treat cancers
NCT ID NCT03162627
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a combination of two drugs, selumetinib and olaparib, in people with advanced or recurrent solid tumors (including ovarian, endometrial, breast, and others) that have specific genetic changes or have stopped responding to similar treatments. The first phase finds the safest dose, and the second phase checks if that dose can help control the cancer. Up to 90 participants will take part at MD Anderson.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- selumetinib and olaparib (drug combination)
- What this could lead to
- If successful, this could point toward a new treatment option for advanced or recurrent solid tumors that have not responded to standard therapies.
- What could go wrong
- This is an early Phase 1 trial, so the main goal is finding a safe dose, not yet proving effectiveness. The combination may cause side effects or not work for many patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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