Proton beam therapy tested for rare skull base tumor

NCT ID NCT00496119

Ongoing Disease control Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase II trial is studying whether proton beam therapy, with or without standard photon radiation, can effectively treat skull base chordoma, a rare tumor at the base of the skull. Nineteen participants who had surgery to remove as much tumor as possible are receiving daily radiation treatments for 35-39 sessions. Researchers are tracking how long it takes for the tumor to come back and how safe the treatment is.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Proton beam therapy (a type of radiation)
What this could lead to: If successful, this could show that proton beam therapy is an effective way to control skull base chordoma and delay or prevent tumor regrowth after surgery.
What could go wrong: This is a small, early-phase trial with only 19 participants, so results may not apply to everyone. The study is no longer recruiting, and it is not yet known if proton therapy is better than standard radiation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CHORDOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

chordoma skull base chordoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHORDOMA

Contacts and locations

Locations

University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.