Which surgery best prevents ovarian cancer without harming sexual health?

NCT ID NCT02760849

Ongoing Prevention Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 16, 2026 · Updated 2 times

Summary

This study looks at two types of surgery to prevent ovarian cancer in women aged 30-50 who have gene mutations that raise their risk. One surgery removes both the fallopian tubes and ovaries, while the other removes only the tubes first and delays removing the ovaries. The goal is to see which approach better lowers cancer risk while also protecting sexual function and emotional well-being.

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Conditions

The condition(s) this trial relates to.

hereditary breast ovarian cancer syndrome ovarian cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DELETERIOUS BARD1 GENE MUTATION DELETERIOUS BRCA1 GENE MUTATION DELETERIOUS BRCA2 GENE MUTATION DELETERIOUS BRIP1 GENE MUTATION DELETERIOUS EPCAM GENE MUTATION DELETERIOUS MLH1 GENE MUTATION DELETERIOUS MSH2 GENE MUTATION DELETERIOUS MSH6 GENE MUTATION DELETERIOUS PALB2 GENE MUTATION DELETERIOUS PMS2 GENE MUTATION DELETERIOUS RAD51C GENE MUTATION DELETERIOUS RAD51D GENE MUTATION HEREDITARY BREAST AND OVARIAN CANCER SYNDROME PREMENOPAUSAL

Contacts and locations

Locations

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States
M D Anderson Cancer Center

Houston, Texas, 77030, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Siteman Cancer Center at Washington University

St Louis, Missouri, 63110, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States
University of Washington Medical Center

Seattle, Washington, 98195, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.