Could a drug replace surgery for some colon cancers?

NCT ID NCT05961709

Ongoing Disease control Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This phase II trial is testing whether the drug cemiplimab can control a specific type of colon cancer (dMMR) without needing surgery. About 50 adults with this cancer type will receive the drug through an IV. The main goal is to see if it is safe and effective enough to avoid an operation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cemiplimab (a drug given by IV)
What this could lead to: If it works, this could offer a way to treat some colon cancers without surgery, using only medication.
What could go wrong: This is a small, early-phase trial with only 50 people. The drug may not work for everyone, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colon adenocarcinoma colon carcinoma colonic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLON CANCER

Contacts and locations

Locations

Banner - MD Anderson Cancer

Gilbert, Arizona, 85234, United States
Baptist - MD Anderson Cancer Center

Jacksonville, Florida, 32207, United States
Cooper University Medical Center

Camden, New Jersey, 08103, United States
M D Anderson Cancer Center

Houston, Texas, 77030, United States
Ochsner

New Orleans, Louisiana, 70121, United States

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