Could a drug replace surgery for some colon cancers?
NCT ID NCT05961709
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase II trial is testing whether the drug cemiplimab can control a specific type of colon cancer (dMMR) without needing surgery. About 50 adults with this cancer type will receive the drug through an IV. The main goal is to see if it is safe and effective enough to avoid an operation.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
cemiplimab (a drug given by IV)
What this could lead to
If it works, this could offer a way to treat some colon cancers without surgery, using only medication.
What could go wrong
This is a small, early-phase trial with only 50 people. The drug may not work for everyone, and side effects are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Banner - MD Anderson Cancer
Gilbert, Arizona, 85234, United States
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Baptist - MD Anderson Cancer Center
Jacksonville, Florida, 32207, United States
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Cooper University Medical Center
Camden, New Jersey, 08103, United States
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
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Ochsner
New Orleans, Louisiana, 70121, United States