New drug combo shows promise for Tough-to-Treat leukemia
NCT ID NCT02756897
First seen Jun 26, 2026 · Last updated Aug 12, 2026 · Updated 5 times
Summary
This phase II trial tests a combination of two targeted drugs, venetoclax and ibrutinib, in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma. The study includes patients whose cancer has come back or is hard to treat, as well as some untreated patients with high-risk features. The goal is to see if this drug pair can control the disease better than standard treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- venetoclax and ibrutinib
- What this could lead to
- If successful, this combination could offer a more effective way to control CLL without chemotherapy, potentially leading to longer remission.
- What could go wrong
- This is a phase II trial, so results are still early. There are risks of serious side effects like infections or bleeding, and it may not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
M D Anderson Cancer Center
Houston, Texas, 77030, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a gentler chemo prep make stem cell transplants safer for blood cancer patients?
- Can a Three-Drug combo outsmart High-Risk CLL?
- Can a gentler dose of zanubrutinib keep CLL at bay in the very elderly?
- Can a Two-Drug combo wipe out hidden leukemia cells?
- Can a Chemo-Free pill combo outsmart leukemia at first diagnosis?