New combo therapy before surgery shows promise for esophageal cancer

NCT ID NCT03784326

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study is testing whether adding two immunotherapy drugs (atezolizumab and tiragolumab) to standard chemotherapy before surgery can help control esophageal or gastroesophageal cancer. About 43 adults with stage II or III cancer will receive the drug combination, then undergo surgery. The main goal is to see if the cancer disappears completely after treatment.

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Conditions

The condition(s) this trial relates to.

esophageal adenocarcinoma gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States