Experimental combo targets Hard-to-Treat esophageal cancer

NCT ID NCT04460937

First seen May 04, 2026 · Last updated May 16, 2026 · Updated 2 times

Summary

This early-stage trial tested a drug called adavosertib combined with radiation for people with advanced esophageal or stomach cancer that cannot be removed by surgery. The goal was to find the safest dose and see how well the combination works. Only 4 people took part, so results are very limited.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • City of Hope Comprehensive Cancer Center

    Duarte, California, 91010, United States

  • Huntsman Cancer Institute/University of Utah

    Salt Lake City, Utah, 84112, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky, 40536, United States

  • University of Pittsburgh Cancer Institute (UPCI)

    Pittsburgh, Pennsylvania, 15232, United States

  • University of Utah Sugarhouse Health Center

    Salt Lake City, Utah, 84106, United States

Conditions

Explore the condition pages connected to this study.

CLINICAL STAGE III ESOPHAGEAL ADENOCARCINOMA AJCC V8 CLINICAL STAGE III ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 CLINICAL STAGE III GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 CLINICAL STAGE IV ESOPHAGEAL ADENOCARCINOMA AJCC V8 CLINICAL STAGE IV ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 CLINICAL STAGE IV GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 CLINICAL STAGE IVA ESOPHAGEAL ADENOCARCINOMA AJCC V8 CLINICAL STAGE IVA ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 CLINICAL STAGE IVA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 CLINICAL STAGE IVB ESOPHAGEAL ADENOCARCINOMA AJCC V8 CLINICAL STAGE IVB ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 CLINICAL STAGE IVB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 DISTAL ESOPHAGUS ADENOCARCINOMA GASTRIC CARDIA ADENOCARCINOMA METASTATIC ESOPHAGEAL ADENOCARCINOMA METASTATIC ESOPHAGEAL SQUAMOUS CELL CARCINOMA METASTATIC GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA METASTATIC MALIGNANT NEOPLASM IN THE BRAIN METASTATIC MALIGNANT NEOPLASM IN THE LEPTOMENINGES PATHOLOGIC STAGE III ESOPHAGEAL ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE III ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 PATHOLOGIC STAGE III GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IIIA ESOPHAGEAL ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IIIA ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 PATHOLOGIC STAGE IIIA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IIIB ESOPHAGEAL ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IIIB ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 PATHOLOGIC STAGE IIIB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IV ESOPHAGEAL ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IV ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 PATHOLOGIC STAGE IV GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IVA ESOPHAGEAL ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IVA ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 PATHOLOGIC STAGE IVA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IVB ESOPHAGEAL ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IVB ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 PATHOLOGIC STAGE IVB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IVB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE III ESOPHAGEAL ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE III ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE III GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IIIA ESOPHAGEAL ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IIIA ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IIIA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IIIB ESOPHAGEAL ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IIIB ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IIIB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IV ESOPHAGEAL ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IV ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IV GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVA ESOPHAGEAL ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVA ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVB ESOPHAGEAL ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVB ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 UNRESECTABLE ESOPHAGEAL ADENOCARCINOMA UNRESECTABLE ESOPHAGEAL CARCINOMA UNRESECTABLE ESOPHAGEAL SQUAMOUS CELL CARCINOMA UNRESECTABLE GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA