New drug cocktail aims to shrink lymphoma without chemo
NCT ID NCT04404088
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase II trial tests a combination of three drugs—acalabrutinib, lenalidomide, and rituximab—in 60 people with untreated follicular lymphoma that has spread. The goal is to see if this chemo-free mix can make the cancer disappear completely. Participants take the drugs by mouth or infusion, and researchers track how many achieve a complete remission.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Acalabrutinib, lenalidomide, and rituximab
- What this could lead to
- If successful, this combination could offer a more effective first-line treatment for follicular lymphoma, potentially leading to higher remission rates without chemotherapy.
- What could go wrong
- This is a small, early-phase (Phase II) study with only 60 participants. The combination may cause side effects like infection, fatigue, or blood clots, and may not prove better than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ANN ARBOR STAGE III GRADE 1 FOLLICULAR LYMPHOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
M D Anderson Cancer Center
Houston, Texas, 77030, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can two immune boosters outsmart follicular lymphoma without chemo?
- Triple-Drug cocktail aims to boost remission in follicular lymphoma
- New drug combo shows promise for untreated lymphoma patients
- New drug cocktail aims to shrink lymphoma tumors without chemo
- New drug duo aims to control lymphoma without chemo
- New drug combo aims to control lymphoma without chemo