Second radiation for brain tumors: a safer approach?

NCT ID NCT02698254

Ongoing Symptom relief Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 16, 2026 · Updated 3 times

Summary

This pilot trial is testing how to safely give a second round of radiation to people whose brain tumors have returned after previous radiation. The study uses special dose limits and the drug bevacizumab to try to reduce brain damage. Forty participants are being followed to see how well they tolerate the treatment and how long they live.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy and bevacizumab (a drug that blocks blood vessel growth)
What this could lead to: If successful, this could help doctors safely give a second round of radiation to people with returning brain tumors, potentially controlling the tumor with fewer side effects.
What could go wrong: This is a very small, early pilot study with only 40 participants, so results may not apply to everyone. There is a risk of brain tissue damage (necrosis) from the radiation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm primary brain neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT BRAIN NEOPLASM

Contacts and locations

Locations

M D Anderson Cancer Center

Houston, Texas, 77030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.