New drug combo shows promise for Tough-to-Treat blood cancers

NCT ID NCT04550442

First seen Nov 01, 2025 · Last updated Apr 29, 2026 · Updated 24 times

Summary

This study tests a combination of two drugs, venetoclax and azacitidine, in about 34 people with high-risk myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) that has returned or not responded to prior treatment. The goal is to find the best dose and see how well the drugs work together to control the cancer. This is not a cure, but aims to manage the disease and improve outcomes.

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Contacts and locations

Locations

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

Conditions

Explore the condition pages connected to this study.