New radiation method may make stem cell transplants safer for older leukemia patients

NCT ID NCT07582172

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a targeted radiation technique (TMLI) combined with two chemotherapy drugs before a stem cell transplant in people aged 50 and older with acute myeloid leukemia or myelodysplastic syndrome that has not responded to treatment or has returned. The goal is to see if this approach can reduce side effects and improve outcomes compared to standard full-body radiation. About 35 participants will receive the treatment and be followed for leukemia-free survival.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia chronic myelomonocytic leukemia myelodysplastic syndrome Myelodysplastic Syndromes therapy related acute myeloid leukemia and myelodysplastic syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • City of Hope Medical Center

    Duarte, California, 91010, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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