Can a poison become a cure? arsenic trioxide put to the test in blood cancer transplant
NCT ID NCT07737769
First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This early-phase trial tests whether adding arsenic trioxide to a standard stem cell transplant can prevent the cancer from coming back in people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The study enrolls about 20 patients whose cancers have a specific genetic flaw (TP53 mutation). The main goal is to check the safety and best dose of arsenic trioxide in this setting, while also watching for signs that it might keep the cancer in remission.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- arsenic trioxide given alongside an allogeneic stem cell transplant
- What this could lead to
- If it works, this could point toward a way to prevent relapse and improve long-term survival for people with high-risk blood cancers.
- What could go wrong
- This is a very early, small phase I trial focused on safety and dosing, so it is unknown whether arsenic trioxide will actually prevent relapse. Arsenic trioxide can cause serious side effects, including heart rhythm problems and liver damage.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, 48109, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a gentler chemo prep make stem cell transplants safer for blood cancer patients?