New drug cocktail targets Hard-to-Treat cancers with gene mutations
NCT ID NCT03065387
First seen Jan 12, 2026 · Last updated Jun 13, 2026 · Updated 24 times
Summary
This early-phase study tests a drug called neratinib combined with one of three other drugs (everolimus, palbociclib, or trametinib) in people with advanced solid tumors that have not responded to standard treatments. The study focuses on tumors with specific gene changes (EGFR, HER2, HER3, HER4, or KRAS). The main goal is to find the safest dose and understand side effects. About 93 adults with advanced or metastatic solid tumors are participating.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
Conditions
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