Simple blood test could spot cancer earlier in High-Risk individuals

NCT ID NCT06726642

Recruiting now Diagnosis Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing a new blood test that looks for DNA fragments from tumors in people with hereditary cancer syndromes like Lynch syndrome or BRCA mutations. The goal is to see if the test can find cancers earlier than standard screening methods. Researchers will compare cancer detection rates between those getting the blood test and those receiving usual care, and also ask participants about their experience. If accurate, this test could offer a simpler, less invasive way to monitor high-risk patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cell-free DNA blood test
What this could lead to: If successful, this blood test could provide a less invasive way to detect cancer earlier in people with inherited cancer risks, potentially improving survival.
What could go wrong: This is an early-stage study testing the test's accuracy. It may not detect all cancers or could give false results. The test is not yet proven for routine use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Colorectal Neoplasms, Hereditary Nonpolyposis gastric neoplasm hereditary breast ovarian cancer syndrome hereditary diffuse gastric adenocarcinoma hereditary neoplastic syndrome Li-Fraumeni syndrome Lynch syndrome neurofibromatosis type 1 PALB2-related cancer predisposition

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEREDITARY CANCER SYNDROME

Contacts and locations

Locations

BC Cancer Agency
NOT_YET_RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
Eastern Health
NOT_YET_RECRUITING

St. John's, Newfoundland and Labrador, A1B 3V6, Canada
IWK Health Centre
NOT_YET_RECRUITING

Halifax, Nova Scotia, B3K 6R8, Canada
Jewish General Hospital
NOT_YET_RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Sinai Health System
RECRUITING

Toronto, Ontario, M5G 1X5, Canada
The Hospital for Sick Children
NOT_YET_RECRUITING

Toronto, Ontario, M5G 1E8, Canada
University Health Network
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Women's College Hospital
NOT_YET_RECRUITING

Toronto, Ontario, M5S 1B2, Canada

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