Simple blood test could spot cancer earlier in High-Risk individuals

NCT ID NCT06726642

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing a new blood test that looks for DNA fragments from tumors in people with hereditary cancer syndromes like Lynch syndrome or BRCA mutations. The goal is to see if the test can find cancers earlier than standard screening methods. Researchers will compare cancer detection rates between those getting the blood test and those receiving usual care, and also ask participants about their experience. If accurate, this test could offer a simpler, less invasive way to monitor high-risk patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

cell-free DNA blood test

What this could lead to

If successful, this blood test could provide a less invasive way to detect cancer earlier in people with inherited cancer risks, potentially improving survival.

What could go wrong

This is an early-stage study testing the test's accuracy. It may not detect all cancers or could give false results. The test is not yet proven for routine use.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Colorectal Neoplasms, Hereditary Nonpolyposis gastric neoplasm hereditary breast ovarian cancer syndrome hereditary diffuse gastric adenocarcinoma hereditary neoplastic syndrome Li-Fraumeni syndrome Lynch syndrome neurofibromatosis type 1 PALB2-related cancer predisposition

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • BC Cancer Agency

    NOT_YET_RECRUITING

    Vancouver, British Columbia, V5Z 4E6, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Email: •••••@•••••

  • Eastern Health

    NOT_YET_RECRUITING

    St. John's, Newfoundland and Labrador, A1B 3V6, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Email: •••••@•••••

  • IWK Health Centre

    NOT_YET_RECRUITING

    Halifax, Nova Scotia, B3K 6R8, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Jewish General Hospital

    NOT_YET_RECRUITING

    Montreal, Quebec, H3T 1E2, Canada

    Contact Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Sinai Health System

    RECRUITING

    Toronto, Ontario, M5G 1X5, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • The Hospital for Sick Children

    NOT_YET_RECRUITING

    Toronto, Ontario, M5G 1E8, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University Health Network

    RECRUITING

    Toronto, Ontario, M5G 2M9, Canada

    Contact Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Women's College Hospital

    NOT_YET_RECRUITING

    Toronto, Ontario, M5S 1B2, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact