New study aims to unlock why lynch syndrome patients still get cancer despite surveillance

NCT ID NCT06708429

Recruiting now Knowledge-focused Sponsor: San Raffaele University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at 300 people with Lynch syndrome, a genetic condition that raises the risk of colorectal cancer. Researchers want to understand why some patients still develop cancer even with regular check-ups. They will analyze blood, gut bacteria, and hair samples to find clues that could lead to better prevention.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to better ways to predict and prevent colorectal cancer in people with Lynch syndrome.
What could go wrong: This is an observational study, so it won't directly test a treatment. Results may not lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal adenoma colorectal cancer colorectal neoplasm Colorectal Neoplasms, Hereditary Nonpolyposis endometrium neoplasm hereditary neoplastic syndrome hereditary nonpolyposis colon cancer Lynch syndrome Lynch syndrome 1 Lynch syndrome 2 mismatch repair cancer syndrome 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEREDITARY CANCER HEREDITARY CANCER SYNDROME HNPCC HNPCC GENE MUTATION LYNCH SYNDROME LYNCH SYNDROME I LYNCH SYNDROME I (SITE-SPECIFIC COLONIC CANCER) LYNCH SYNDROME II MLH1 GENE DELETION+DUPLICATION MLH1 GENE INACTIVATION MLH1 GENE MUTATION MLH1 LOSS OF EXPRESSION MSH2 GENE DELETION+DUPLICATION MSH2 GENE INACTIVATION MSH2 GENE MUTATION MSH2 LOSS OF EXPRESSION MSH6 GENE INACTIVATION MSH6 GENE MUTATION MSH6 LOSS OF EXPRESSION PMS2 GENE INACTIVATION PMS2 GENE MUTATION PMS2 LOSS OF EXPRESSION

Contacts and locations

Locations

Beckman Research Institute at City of Hope
RECRUITING

Monrovia, California, 91016, United States
Chirurgia Generale, Azienda Ospedaliero Universitaria di Cagliari
RECRUITING

Cagliari, Italy
Dipartimento di Chirurgia Oncologica e Dipartimento di Oncologia Sperimentale Istituto Nazionale Tumori
RECRUITING

Milan, MI, Italy
Dipartimento di controllo qualità e rischio chimico biologico, AOOR Villa Sofia Cervello
RECRUITING

Palermo, PM, Italy
Gastronterology and Gastrointestinal Endoscopy Unit, IRCCS San Raffaele Hospital
RECRUITING

Milan, Lombardy, 20132, Italy

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