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New study aims to unlock why lynch syndrome patients still get cancer despite surveillance

NCT ID NCT06708429

Recruiting now Knowledge-focused Sponsor: San Raffaele University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at 300 people with Lynch syndrome, a genetic condition that raises the risk of colorectal cancer. Researchers want to understand why some patients still develop cancer even with regular check-ups. They will analyze blood, gut bacteria, and hair samples to find clues that could lead to better prevention.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this could lead to better ways to predict and prevent colorectal cancer in people with Lynch syndrome.

What could go wrong

This is an observational study, so it won't directly test a treatment. Results may not lead to immediate changes in care.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

colorectal adenoma colorectal cancer colorectal neoplasm Colorectal Neoplasms, Hereditary Nonpolyposis endometrium neoplasm hereditary neoplastic syndrome hereditary nonpolyposis colon cancer Lynch syndrome Lynch syndrome 1 Lynch syndrome 2 mismatch repair cancer syndrome 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEREDITARY CANCER HEREDITARY CANCER SYNDROME HNPCC HNPCC GENE MUTATION LYNCH SYNDROME LYNCH SYNDROME I LYNCH SYNDROME I (SITE-SPECIFIC COLONIC CANCER) LYNCH SYNDROME II MLH1 GENE DELETION+DUPLICATION MLH1 GENE INACTIVATION MLH1 GENE MUTATION MLH1 LOSS OF EXPRESSION MSH2 GENE DELETION+DUPLICATION MSH2 GENE INACTIVATION MSH2 GENE MUTATION MSH2 LOSS OF EXPRESSION MSH6 GENE INACTIVATION MSH6 GENE MUTATION MSH6 LOSS OF EXPRESSION PMS2 GENE INACTIVATION PMS2 GENE MUTATION PMS2 LOSS OF EXPRESSION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Beckman Research Institute at City of Hope

    RECRUITING

    Monrovia, California, 91016, United States

    Contact Email: •••••@•••••

  • Chirurgia Generale, Azienda Ospedaliero Universitaria di Cagliari

    RECRUITING

    Cagliari, Italy

    Contact

    Contact

  • Dipartimento di Chirurgia Oncologica e Dipartimento di Oncologia Sperimentale Istituto Nazionale Tumori

    RECRUITING

    Milan, MI, Italy

    Contact

    Contact

  • Dipartimento di controllo qualità e rischio chimico biologico, AOOR Villa Sofia Cervello

    RECRUITING

    Palermo, PM, Italy

    Contact

  • Gastronterology and Gastrointestinal Endoscopy Unit, IRCCS San Raffaele Hospital

    RECRUITING

    Milan, Lombardy, 20132, Italy

    Contact

    Contact

    Contact

    Contact

    Contact Email: •••••@•••••

    Contact

    Contact

    Contact