Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a custom vaccine stop cancer before it starts in lynch syndrome?

NCT ID NCT07163403

Recruiting now Prevention Sponsor: Fundacion Clinic per a la Recerca Biomédica Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tests a personalized vaccine made from a person's own immune cells (dendritic cells) loaded with unique proteins found in Lynch syndrome-related cancers. The goal is to train the immune system to recognize and attack precancerous cells, potentially preventing cancer. Twenty Lynch syndrome carriers with no current cancer will receive six vaccine doses over 10 weeks, with researchers monitoring safety and immune response for a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
dendritic cells loaded with frameshift-derived neopeptides (a personalized vaccine made from the patient's own immune cells)
What this could lead to
If it works, this could lead to a vaccine that prevents cancer in people with Lynch syndrome, reducing their high lifetime cancer risk.
What could go wrong
This is a very early, small Phase 1 trial with only 20 people, so it may not show strong results or work for everyone. The main goal is safety, not yet effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for LYNCH SYNDROME are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Colorectal Neoplasms, Hereditary Nonpolyposis Lynch syndrome cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYNCH SYNDROME

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Laura Burunat

    RECRUITING

    Barcelona, Barcelona, 08036, Spain

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

More trials for these conditions

Other studies related to the condition(s) this trial covers.