Stool test could ease cancer screening for lynch syndrome patients

NCT ID NCT06898996

Recruiting now Diagnosis Sponsor: University of Chicago Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a fecal immunochemical test (FIT), which checks for blood in the stool, can accurately detect colorectal cancer in people with Lynch Syndrome. Lynch Syndrome increases the risk of colorectal cancer, and patients currently need regular colonoscopies. The study will compare FIT results to colonoscopy findings in 400 participants to see how well the simpler test works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fecal immunochemical test (FIT)
What this could lead to: If successful, this could offer a less invasive, more convenient screening option for people with Lynch Syndrome, potentially reducing the need for frequent colonoscopies.
What could go wrong: This is an early-stage study focused on accuracy, not treatment. FIT may miss some cancers that colonoscopy would find, and results may not apply to all Lynch Syndrome patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm Colorectal Neoplasms, Hereditary Nonpolyposis Lynch syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER

Contacts and locations

Locations

Columbia University
RECRUITING

New York, New York, 10032, United States
The University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60639, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States

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