Pill cameras could spot rare gut cancers in lynch syndrome patients

NCT ID NCT05704010

Recruiting now Knowledge-focused Sponsor: San Raffaele University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a swallowed video capsule (a pill-sized camera) can help find small bowel cancer early in people with Lynch syndrome, a genetic condition that raises cancer risk. About 100 participants will swallow a capsule every two years to take pictures of their small intestine. The goal is to measure how often pre-cancerous growths or cancers appear, which could guide future screening recommendations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Video capsule endoscopy (a pill-sized camera swallowed to take pictures of the small intestine)
What this could lead to: If successful, this study could show that regular video capsule endoscopy helps detect small bowel cancer early in people with Lynch syndrome, potentially improving outcomes.
What could go wrong: This is an observational registry, not a treatment trial. It will not test whether screening actually saves lives, and the capsule may miss some lesions. Results will take years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Colorectal Neoplasms, Hereditary Nonpolyposis Lynch syndrome Lynch syndrome 1 Lynch syndrome 2 small intestine adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYNCH SYNDROME LYNCH SYNDROME I LYNCH SYNDROME II MLH1 GENE MUTATION MSH2 GENE MUTATION MSH6 GENE MUTATION PMS2 GENE MUTATION SMALL BOWEL ADENOCARCINOMA

Contacts and locations

Locations

San Raffaele Scientific Institute, Gastroenterology and Gastrointestinal Endoscopy Unit
RECRUITING

Milan, Lombardy, 20132, Italy

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