Supercharged t cells take on Hard-to-Treat cancers
NCT ID NCT07614048
First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 2 times
Summary
This treatment program tests a personalized cell therapy for people with advanced pancreatic or colorectal cancers that have a specific genetic mutation (KRAS G12D). Patients' own immune cells are collected, genetically engineered to recognize and attack the cancer, and then infused back after a short course of chemotherapy. The goal is to control the disease in patients who have run out of standard options.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- engineered T cells (TCR-T cells) targeting mutant KRAS
- What this could lead to
- If successful, this could offer a new treatment option for patients with advanced pancreatic or colorectal cancers that have not responded to standard therapies.
- What could go wrong
- This is an early-stage expanded access program, not a large controlled trial. The treatment may not shrink tumors or improve survival, and there are risks from chemotherapy and cell infusion, including severe immune reactions.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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