RETINOBLASTOMA

This early-stage trial tests a new treatment called GPC2 CAR T cells for children with advanced neuroblastoma or retinoblastoma that has come back or not responded to standard therapy. The treatment uses the patient's own immune cells, modified in a lab to better recognize and at…

This study tests a chemotherapy patch placed on the eye to treat advanced or recurrent retinoblastoma in children under 8. The goal is to save the eye from removal. Researchers will check safety and how well the patch works in 30 participants.

This study tests two new chemotherapy strategies to treat retinoblastoma, a rare eye cancer in children, while trying to save the eye and preserve vision. One part compares a two-drug injection directly into the eye's artery versus a single drug. The other part looks at standard …

This study tests a set of treatment guidelines for children with retinoblastoma, a rare eye cancer, in African hospitals. The goal is to improve survival rates by catching the disease early and following proven treatment steps. About 3,000 children with different stages of the di…

This study looks at whether a special MRI scan can predict how well children with retinoblastoma (a rare eye cancer) will respond to chemotherapy delivered directly to the eye. Researchers will follow 60 children for 18 months after treatment to see if the MRI findings match the …

This study collects extra blood, urine, and tumor samples from children and adults with childhood cancers (like leukemia or sarcoma) to create a large tissue repository. Researchers will use these samples to study the genetic and molecular makeup of these cancers. The goal is to …

This research study aims to discover new genes that may cause cancer to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had childhood cancers. Participants will not receive direct treatment o…

This study collects medical information and a small sample of eye fluid from children diagnosed with retinoblastoma, a rare eye cancer. Researchers want to find biological markers in the fluid that can predict whether the eye can be saved with treatment. Up to 800 children treate…

This study follows 900 people with retinoblastoma and their family members over time to learn about the disease's causes, long-term health effects, and best treatments. Researchers will collect vision tests, tissue and saliva samples, and questionnaires. The goal is to improve ca…

This study looks at the genes of people with retinoblastoma, a rare eye cancer in children. Researchers will analyze DNA from 100 participants to learn how changes in the RB1 gene cause cancer. The goal is to better understand the disease, not to test a new treatment.