RETINOBLASTOMA

This phase 2 trial tests a chemotherapy eye implant (Episcleral Topotecan) in 30 children under 8 with advanced or recurrent retinoblastoma. The goal is to see if the implant can safely treat the eye tumor and avoid the need to remove the eye. Researchers are checking for side ef…

This study aims to improve survival and care for children with retinoblastoma, a rare eye cancer, in low-income African countries. Researchers will test whether following a set of treatment guidelines helps catch the disease early and leads to better outcomes. The study will enro…

This early-stage trial is testing a new treatment called GPC2 CAR T cells for children with neuroblastoma or retinoblastoma that has come back or not responded to standard treatments. The therapy uses a patient's own immune cells, which are modified in a lab to better recognize a…

This study tests two ways to treat retinoblastoma, a childhood eye cancer, while trying to save the eye and vision. One part compares two types of artery-directed chemotherapy (one with two drugs, one with one) to see which better preserves the eye. The other part looks at how we…

This study collects extra blood, urine, and tumor samples from children and adults with certain cancers to build a large tissue repository. Researchers will analyze these samples to learn more about the genetic and molecular makeup of these tumors. The goal is to support future s…

This study aims to discover new genes that may cause certain cancers to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had cancer, especially childhood cancers. The goal is to build a regist…

This study compares brain development in children who had multiple anesthesia exposures during retinoblastoma treatment to children who never had anesthesia. Researchers will use intelligence and memory tests to see if there are differences. The goal is to understand if anesthesi…

This study collects medical information and fluid from the front of the eye (aqueous humor) from up to 800 children with retinoblastoma, a rare eye cancer. Researchers aim to find biological markers in the fluid that can predict whether the eye can be saved with treatment. The st…

This study looks at the genes of 100 people with retinoblastoma, a rare eye cancer, to learn how changes in the RB1 gene cause the disease and related cancers. Participants give a blood or saliva sample for genetic testing. The goal is to better understand the link between a pers…

This study is testing whether a special type of MRI scan can predict how children with retinoblastoma, a rare eye cancer, will respond to chemotherapy delivered directly to the eye. Researchers will scan 60 children before treatment and check if the scan results match their respo…

This study follows 900 children who were treated for retinoblastoma, a rare eye cancer, to track their long-term health. Researchers will collect vision tests, tissue and saliva samples, and questionnaires from patients and their siblings. The goal is to learn more about what cau…