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Chemo plaque could spare Kids' eyes from removal

NCT ID NCT06679634

Recruiting now Disease control Sponsor: Targeted Therapy Technologies, LLC Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests a chemotherapy eye implant (Episcleral Topotecan) in 30 children under 8 with advanced or recurrent retinoblastoma. The goal is to see if the implant can safely treat the eye tumor and avoid the need to remove the eye. Researchers are checking for side effects and how well the drug works at different doses.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Episcleral Topotecan (chemotherapy eye implant)
What this could lead to
If successful, this could offer a way to save eyes with advanced retinoblastoma, avoiding removal while controlling the cancer.
What could go wrong
This is a small, early-phase trial (30 children) focused on safety and dosing. It may not work for all, and side effects from the chemotherapy implant are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

retinoblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RETINOBLASTOMA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Children's Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • NewYork Presbyterian Morgan Stanley Children's Hospital

    RECRUITING

    New York, New York, 10032, United States

    Contact Phone: •••-•••-••••

    Contact Phone: •••-•••-••••

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