New drug aims to keep leukemia away after transplant

NCT ID NCT06575296

Recruiting now Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tests a drug called revumenib in people with acute leukemia who have had a stem cell transplant. The drug targets a protein that helps leukemia cells grow. The study will check safety, find the best dose, and see if it can stop the cancer from coming back. About 27 adults and children with specific genetic changes (KMT2A or NPM1 mutations) will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Revumenib (a menin inhibitor)
What this could lead to: If it works, this could help prevent leukemia from coming back after a stem cell transplant, offering a new maintenance option for patients with certain genetic mutations.
What could go wrong: This is a very early (Phase 1) trial with only 27 participants, so safety and dosing are still being figured out. It may not work or could cause serious side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute biphenotypic leukemia acute leukemia acute leukemia of ambiguous lineage acute lymphoblastic leukemia acute myeloid leukemia acute myeloid leukemia with mutated NPM1 acute myeloid leukemia, MLL gene rearrangement childhood acute lymphoblastic leukemia childhood acute myeloid leukemia childhood leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LEUKEMIA ACUTE LEUKEMIA OF AMBIGUOUS LINEAGE ACUTE LYMPHOBLASTIC LEUKEMIA ACUTE MYELOID LEUKEMIA CHILDHOOD ACUTE LEUKEMIA CHILDHOOD ACUTE LEUKEMIA OF AMBIGUOUS LINEAGE CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA CHILDHOOD ACUTE MYELOID LEUKEMIA

Contacts and locations

Locations

City of Hope Medical Center
RECRUITING

Duarte, California, 91010, United States

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