ACUTE LEUKEMIA

This study tests a new way to prevent chronic graft-versus-host disease (GVHD) in children and young adults with blood cancers who receive a donor stem cell transplant. Researchers remove a specific type of immune cell (naive T cells) from the donor cells before transplant to red…

This early-stage study tests the safety of a new drug called ziftomenib when combined with standard chemotherapy for people whose acute myeloid leukemia (AML) has returned or not responded to treatment. The study includes adults with specific genetic changes (NPM1 mutation or KMT…

This study tests a new drug called bleximenib for people with acute leukemia that has come back or not responded to other treatments. The drug targets specific genetic changes in the cancer cells. The study will first find the best dose and then check if it can safely help patien…

This study tests whether adding a precise, targeted form of radiation to the usual chemotherapy before a stem cell transplant can kill more cancer cells in the bone marrow and lower the chance of the disease coming back. It involves 27 adults aged 18-75 with acute leukemia or mye…

This program provides an experimental drug called AVM0703 to people with various cancers, including brain tumors, breast cancer, and leukemia. It is available in the US when a doctor requests it. So far, 37 patients have received the treatment, and side effects have been mostly m…

This study tests two different methods to lower the risk of graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body, after a stem cell transplant. The trial includes 120 adults with acute leukemia or myelodysplastic syndrome (MDS) whos…

This study looks at whether menin inhibitors can help prevent leukemia from coming back after a stem cell transplant. About 20 people with certain genetic types of acute leukemia will take these drugs as part of their regular care. Researchers will track how long they stay cancer…

This study tests a new way to prepare stem cells for transplant in children and adults with blood cancers like leukemia. The method removes certain immune cells to lower the risk of graft-versus-host disease, a serious side effect. About 70 participants will receive the treatment…

This study tests whether combining three drugs—tacrolimus, methotrexate, and a new dosing schedule of anti-thymocyte globulin—can prevent acute graft-versus-host disease (GVHD) in people receiving stem cell transplants for blood cancers like leukemia. About 29 adults aged 18-60 w…

This study tests a stem cell transplant approach for people with blood cancers like AML and MDS. It uses milder chemotherapy (treosulfan and fludarabine) followed by a donor stem cell infusion, plus drugs to prevent graft-versus-host disease. The goal is to improve survival at 10…

This study tests a new radioactive drug (177Lu-PentixaTher) for people with acute leukemia that has come back or not responded to other treatments. The drug seeks out and delivers radiation to leukemia cells that have a specific marker (CXCR4). The main goals are to find the safe…

This early-phase study tests whether bone marrow from deceased donors can be safely used for people with blood cancers like leukemia and lymphoma. About 12 patients will receive a transplant after chemotherapy, and doctors will monitor for side effects and blood cell recovery for…

This study tests whether adding specially prepared donor immune cells can help children recover from stem cell transplants faster and avoid dangerous infections. Participants are children under 25 with high-risk blood cancers who have already received a transplant. The goal is to…

This study tests a drug called luspatercept to treat anemia (low red blood cells) that can happen after a stem cell transplant for acute leukemia. About 46 people will get two shots of the drug in the first month after transplant. The goal is to see if it safely raises hemoglobin…

This study is for people with certain blood cancers, like leukemia or lymphoma. It tests a stem cell transplant from a half-matched donor, using a special drug combo (treosulfan and fludarabine) plus low-dose radiation to prepare the body. The goal is to see if this approach help…

This study tests whether combining two drugs, revumenib and mezigdomide, is safe for people with certain types of acute leukemia that have come back or not responded to treatment. The trial includes about 52 participants aged 12 and older with specific genetic changes in their le…

This study looks at how well umbilical cord blood stem cells from unrelated donors can restore blood cell counts in people with serious blood cancers, immune deficiencies, or genetic disorders. Researchers will track how often the transplant succeeds, how long it takes for blood …

This study tests a new experimental drug, LP-118, combined with three other medicines (ponatinib, vincristine, and dexamethasone) in adults with T-cell acute lymphoblastic leukemia or lymphoma that has come back or not responded to treatment. The main goals are to find a safe dos…

This early-phase study tests a new oral drug, BY002, in about 18 adults with acute leukemia that has come back or not responded to standard treatments. The drug targets specific genetic changes (KMT2A rearrangements or NPM1 mutations) to control the disease. The main goals are to…

This early-phase study tests the safety and best dose of revumenib, a drug that blocks a protein fueling leukemia growth, in 27 adults and children with specific genetic types of acute leukemia. Participants take revumenib after a stem cell transplant to help keep the cancer from…

This study tests two different low doses of total body irradiation (200 vs 400 cGy) given before a stem cell transplant for people with acute leukemia. The goal is to see which dose better prevents severe graft-versus-host disease, relapse, and death. About 160 participants will …

This study tests a two-step method of giving an anti-rejection drug (ATG) along with standard medications to prevent severe graft-versus-host disease (GVHD) in people with blood cancers receiving a stem cell transplant. About 56 adults aged 18-75 will participate. The goal is to …

This study is testing a new platform that uses advanced testing to better understand different types of cancer, including leukemia, myeloma, and solid tumors. The goal is to see if this platform can change the recommended treatment for patients, making it more personalized. About…

This study looks at whether a formal care support program can help lower anxiety in people who have just been told they have acute leukemia. About 110 adults aged 26 to 79 with a new diagnosis will take part. Half will get the extra support, and the other half will not, so resear…

This study tests a program called EASE that combines psychological support with regular symptom checks and early access to palliative care. It is for people recently diagnosed with acute leukemia. Half of the 266 participants will get usual care, and half will get usual care plus…

This study tests whether using virtual reality (VR) during needle placement can reduce pain and fear in children aged 6 to 16 with acute leukemia. About 120 participants will be randomly assigned to receive either standard care or VR during each needle stick over three months. Th…

This research study aims to discover new genes that may cause cancer to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had childhood cancers. Participants will not receive direct treatment o…

This study examines gynecological complications and infertility in women who received a stem cell transplant for acute leukemia as adults. Researchers will review medical records of 80 women to see how common issues like early menopause, vaginal graft-versus-host disease, and cer…

This study looks at blood cancer cells from 250 patients to understand which drugs might work best. Researchers will test many approved and experimental drugs on these cells in the lab. The goal is to find new treatment targets and match them to each patient's cancer type. This i…

This study is collecting blood, bone marrow, and tissue samples from over 1,000 people with blood cancers like leukemia and myeloma. Researchers will use advanced lab techniques to find unique markers (biomarkers) for each cancer type. The goal is to better understand these disea…

This study watches over 1,300 people with blood cancers like acute leukemia to see how many get a stem cell transplant and why some don't. It aims to find barriers that stop patients from receiving this treatment, even when doctors recommend it. No new treatments are tested—just …