ACUTE LEUKEMIA

This study tests a new treatment called Orca-T for people with advanced blood cancers (like leukemia) who need a stem cell transplant. Orca-T is made from a donor's cells and includes special immune cells to help prevent a serious side effect called graft-versus-host disease (GVH…

This study planned to test whether banked, frozen bone marrow from partially matched donors could be safely used for transplants in people with blood cancers like leukemia. Participants would have received a transplant followed by drugs to prevent graft-versus-host disease. The s…

This study tests a stem cell transplant using donors who are not a perfect match for people with blood cancers like leukemia or lymphoma. The goal is to see if adding certain drugs after the transplant can prevent complications and improve survival. About 300 adults and children …

This early-phase study tests a new way to do stem cell transplants for people with advanced blood cancers like leukemia. Instead of using strong drugs to prevent complications, doctors will give patients specially prepared immune cells (regulatory T-cells) along with regular dono…

This early-phase study tests a precise radiation method (IMRT) to deliver total body irradiation while reducing the dose to the lungs. The goal is to prevent lung side effects in 20 adults with acute leukemia or myelodysplastic syndrome undergoing a stem cell transplant. Research…

This study tests whether a lower dose of the drug cyclophosphamide, given after a stem cell transplant from a partially matched donor, can reduce serious infections while still preventing graft-versus-host disease (a condition where donor cells attack the patient's body). About 3…

This study looks at whether training parents in specific skills can improve learning and school functioning for Latino children with acute leukemia or lymphoma. About 214 families will take part, with some parents receiving a high-intensity program and others getting standard sup…

This study tests a fast, motion-resistant brain MRI technique called Magnetic Resonance Fingerprinting (MRF) in children, teens, and young adults with acute leukemia. The goal is to see if the scan can detect brain changes caused by chemotherapy drugs that enter the brain. Partic…

This study looks at blood and bone marrow samples from 50 children and young adults (ages 1 month to 30 years) with newly diagnosed or relapsed acute leukemia. Researchers will use advanced gene sequencing to find changes in specific genes like ARID5B and SALL4 that may be linked…

This study aims to find the genetic causes of blood and bone marrow cancers, such as leukemia. Researchers will look for specific cell abnormalities that drive cancer growth. Up to 5,000 people with these cancers will provide samples for analysis. The goal is to develop more effe…

This study tests whether a special website and video coaching for parents can help children aged 6-12 who were treated for leukemia or lymphoma improve their learning and school performance. Many children survive these cancers but may struggle with memory, attention, and thinking…