New radiation technique aims to protect lungs during stem cell transplants

NCT ID NCT04281199

Ongoing Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This early-phase study tests a new way to deliver total body radiation before a stem cell transplant for people with acute leukemia or myelodysplastic syndrome. The goal is to reduce radiation to the lungs to prevent serious lung damage. Twenty participants will receive intensity-modulated radiation therapy (IMRT) instead of standard total body irradiation, and researchers will track side effects and treatment success.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Intensity-modulated radiation therapy (IMRT) with total body irradiation
What this could lead to: If successful, this approach could reduce lung side effects and improve survival for patients needing a stem cell transplant.
What could go wrong: This is a small, early-phase pilot study with only 20 participants, so results may not apply broadly. The new radiation technique may still cause lung problems or other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute leukemia myelodysplastic syndrome Myelodysplastic Syndromes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LEUKEMIA MYELODYSPLASTIC SYNDROME

Contacts and locations

Locations

City of Hope Medical Center

Duarte, California, 91010, United States

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