New cord blood matching method could expand transplant access for blood cancer patients

NCT ID NCT01810588

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests a new approach to stem cell transplants for people with blood cancers like leukemia and lymphoma. Patients receive a combination of umbilical cord blood and stem cells from a family member, with the cord blood chosen based on specific genetic markers rather than just cell count. The goal is to see if this matching method leads to successful engraftment and better long-term survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

stem cell transplant (haploidentical donor cells and umbilical cord blood)

What this could lead to

If successful, this could make stem cell transplants safer and more available for people with blood cancers who lack a perfect donor match.

What could go wrong

This is a mid-stage trial with 270 participants, so results are not yet proven. The procedure carries risks like infection, graft failure, and side effects from chemotherapy.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

acute leukemia acute lymphoblastic leukemia acute myeloid leukemia aplastic anemia B-cell chronic lymphocytic leukemia CD4+/CD56+ hematodermic neoplasm chronic myelogenous leukemia, BCR-ABL1 positive hematopoietic and lymphoid system neoplasm hemoglobinopathy Hodgkins lymphoma lymphoma lymphosarcoma myelodysplastic syndrome Myeloproliferative Disorders myeloproliferative neoplasm plasma cell myeloma plasma cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Chicago Medical Center

    Chicago, Illinois, 60637, United States

  • Weill Cornell Medical College

    New York, New York, 10065, United States