Could dead donors provide Life-Saving bone marrow?

NCT ID NCT05589896

Ongoing Disease control Sponsor: Ossium Health, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 2 times

Summary

This early study is testing whether bone marrow from deceased donors can be safely used for transplants in people with blood cancers like leukemia and lymphoma. Twelve patients will receive the transplant along with chemotherapy or radiation. The main goal is to see if the new marrow starts making blood cells and to check for serious side effects over the first year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bone marrow from a deceased donor
What this could lead to: If successful, this could provide a new source of bone marrow for transplants, potentially helping more patients with blood cancers who lack a living donor.
What could go wrong: This is a very early, small trial (12 people) focused on safety. The approach may fail to engraft or cause serious side effects, and it's unknown if it will work as well as standard living-donor transplants.

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Conditions

The condition(s) this trial relates to.

acute biphenotypic leukemia acute leukemia acute lymphoblastic leukemia acute myeloid leukemia acute undifferentiated leukemia B-cell chronic lymphocytic leukemia chronic myelogenous leukemia, BCR-ABL1 positive hematologic disorder Hodgkins lymphoma leukemia Leukemia, B-Cell Leukemia, Myelogenous, Chronic, BCR-ABL Positive lymphoma myelodysplastic syndrome myelodysplastic syndrome with excess blasts non-Hodgkin lymphoma Precursor Cell Lymphoblastic Leukemia-Lymphoma primary cutaneous T-cell non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE BIPHENOTYPIC LEUKEMIA ACUTE LEUKEMIA ACUTE LYMPHOBLASTIC LEUKEMIA ACUTE MYELOID LEUKEMIA ACUTE UNDIFFERENTIATED LEUKEMIA CHRONIC MYELOID LEUKEMIA (CML) CLL (CHRONIC LYMPHOCYTIC LEUKEMIA) CUTANEOUS T CELL LYMPHOMAS (CTCL) HODGKINS LYMPHOMA MDS (MYELODYSPLASTIC SYNDROME) NON-HODGKIN LYMPHOMAS

Contacts and locations

Locations

City of Hope

Duarte, California, 91010, United States
Emory University - Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Henry Ford Cancer Institute

Detroit, Michigan, 48202, United States
Methodist Hospital, Texas Transplant

San Antonio, Texas, 78229, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
St. David's South Austin Medical Center

Austin, Texas, 78745, United States
TriStar Bone Marrow Transplant

Nashville, Tennessee, 37203, United States
University of Utah - Huntsman Cancer Institute

Salt Lake City, Utah, 84112, United States

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