New stem cell therapy aims to tame transplant complications
NCT ID NCT04013685
First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 1 time
Summary
This study tests a new treatment called Orca-T for people with advanced blood cancers like leukemia. It uses a special mix of stem cells and immune cells from a donor to help the body accept the transplant while reducing serious side effects like graft-versus-host disease. The goal is to improve survival and quality of life after a stem cell transplant.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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City of Hope
Duarte, California, 91010, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Colorado Blood Cancer Institute
Denver, Colorado, 80218, United States
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Massachusetts
Boston, Massachusetts, 02114, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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OU Health Stephenson Cancer Center
Oklahoma City, Oklahoma, 73104, United States
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Oregon Health & Sciences University - Knight Cancer Institute
Portland, Oregon, 97239, United States
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Ronald Reagan UCLA Medical Center
Los Angeles, California, 90095, United States
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Sarah Cannon Research Institute
Nashville, Tennessee, 37203, United States
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Stanford Health Care
Stanford, California, 94305, United States
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The University of Kansas Hospital
Kansas City, Kansas, 66160, United States
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UC Davis
Sacramento, California, 95817, United States
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University of Chicago
Chicago, Illinois, 60637, United States
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University of Miami Hospital and Clinics - Sylvester Comprehensive Cancer Center
Miami, Florida, 33136, United States
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University of Michigan Health System - Michigan Medicine
Ann Arbor, Michigan, 48109, United States
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77054, United States
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University of Utah - Huntsman Cancer Institute
Salt Lake City, Utah, 84112, United States
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Vanderbilt University
Nashville, Tennessee, 37232, United States
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Weill Cornell Medicine - New York-Presbyterian Hospital
New York, New York, 10021, United States
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Winship Cancer Institute - Emory University
Atlanta, Georgia, 30322, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Could muscle loss predict blood cancer outcomes?
- Can a modified enzyme starve Hard-to-Treat blood cancers?
- Can a Low-Dose antifungal shield vulnerable patients from deadly fungal infections?
- Can a gentler chemo prep make stem cell transplants safer for blood cancer patients?
- Talking about the end: could guided conversations reduce futile cancer treatments?