Can a simple blood test predict radiation success in rare spine tumors?

NCT ID NCT06463262

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether changes in tumor DNA found in the blood and special imaging scans can predict how well chordoma tumors respond to radiation therapy given before surgery. About 40 adults with chordoma of the spine, skull base, or sacrum will receive proton therapy or stereotactic body radiation therapy. The goal is to see if these markers can replace the current method of checking tumor response after surgery, making treatment monitoring less invasive.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

sacrum chordoma skull base chordoma spinal chordoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Johns Hopkins Hospital

    RECRUITING

    Baltimore, Maryland, 212887, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••