Can a cancer drug tame a dangerous immune storm?
NCT ID NCT07424222
First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 4 times
Summary
This early study tests the drug ruxolitinib for a rare but serious condition called IEC-HS, which can happen after CAR-T therapy for cancer. The condition causes a dangerous overreaction of the immune system. The trial will include 16 adults and aims to see if the drug is safe and can control the overreaction.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ruxolitinib (brand name Jakafi), a drug taken orally to calm an overactive immune response.
- What this could lead to
- If it works, this could point toward a treatment for a rare but serious immune complication after CAR-T therapy.
- What could go wrong
- This is a very early, small pilot study with only 16 people. It may not show clear benefit, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
RECRUITINGBaltimore, Maryland, 21287, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.