Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins

This early study tested the safety and feasibility of the TA-CIN vaccine in 15 people who had been treated for HPV16-related cervical cancer and were cancer-free at the time. The goal was to see if the vaccine could be given safely and whether it triggered an immune response that…

This study tested a combination of two drugs, copanlisib and nivolumab, in 48 adults with advanced solid tumors, specifically a type of colorectal cancer called MSS that hasn't responded to standard treatments. The goal was to see if the combination could shrink or control tumors…

This study tested a combination of four drugs (CRS-207, pembrolizumab, ipilimumab, and tadalafil) in 17 adults with metastatic pancreatic cancer that had worsened after at least one prior chemotherapy. The goal was to see if the treatment could shrink tumors and to check its safe…

This study tested a bone marrow transplant using donors who are not perfectly matched or first-degree relatives, for people with blood cancers. The goal was to see if this approach could control the cancer with acceptable side effects like graft-versus-host disease. 87 participan…

This early-phase study tested a combination of three immunotherapy drugs (nivolumab, BMS-813160, and GVAX) in 22 adults with locally advanced pancreatic cancer that could not be removed by surgery. All participants had already received chemotherapy and radiation. The main goals w…

This study tested a drug called pemigatinib in 30 people with a type of bladder cancer that keeps coming back. Participants took the drug for 4-6 weeks before their scheduled surgery to remove the tumor. The goal was to see if the drug could completely eliminate the cancer before…

This study tested a combination of a pancreatic cancer vaccine (GVAX), an immunotherapy drug (pembrolizumab), and focused radiation (SBRT) in 58 people with locally advanced pancreatic cancer. The goal was to see if this mix could delay the cancer from spreading to other parts of…

This study tested a new way to give testosterone therapy to men with a type of advanced prostate cancer that no longer responds to standard hormone therapy. Instead of injections, patients took oral testosterone for seven days, then stopped for seven days, repeating this cycle. I…

This study tested the drug nivolumab in 8 men whose prostate cancer returned after initial treatment and who had specific genetic changes (MMR-deficient or CDK12-altered). The goal was to see if nivolumab could lower PSA levels without using hormone therapy. While the approach of…

This early-stage study tested a drug called flotetuzumab in 3 adults whose acute myeloid leukemia (AML) came back after a stem cell transplant. The main goal was to see if the drug is safe and find the best dose. Researchers also looked at whether the drug could help control the …

This study tested a combination of two drugs (durvalumab and SNDX-6352) in 5 adults with a type of liver cancer that cannot be surgically removed. The goal was to see if the combo could shrink tumors or slow the cancer after standard liver-directed treatments. The trial focused o…

This early-phase study tested whether adding two drugs (romidepsin and 5-azacitidine) to an immunotherapy (MK-3475) could help people with a specific type of advanced colorectal cancer called microsatellite stable (MSS). The study included 27 adults whose cancer had already sprea…

This study tested whether adding a bone-targeting drug (Radium-223) to precise radiation therapy (SABR) helps men with prostate cancer that has spread to a few spots (oligometastatic). Sixty-four men participated, and the main goal was to see how long the cancer stayed under cont…

This early-phase study tested whether giving two immunotherapy drugs (nivolumab and ipilimumab) before standard treatments like surgery or radiation is safe and feasible for people with Neurofibromatosis Type 1 (NF1) who have a rare nerve tumor called MPNST. The trial enrolled 13…

This study tested whether adding the drug enzalutamide to standard radiation therapy can better control prostate cancer that has come back after surgery. 86 men with rising PSA levels after prostate removal took part. The goal was to see if the combination could delay cancer prog…

This study tested a combination of targeted radiation therapy and a short course of hormone therapy in 45 men with intermediate-risk prostate cancer. The goal was to see how well the treatment controlled the cancer over 5 years and what side effects occurred. The approach aims to…

This study tested a shorter course of radiation therapy (16 sessions instead of the usual 40+) for men with early-stage prostate cancer. The goal was to see if this approach is safe and effective at controlling the cancer while reducing side effects. Researchers tracked urinary, …

This study tested a personalized home exercise program for cancer survivors who also have diabetes or high blood pressure. Thirty-four participants chose from four exercise options (like walking or yoga) and used a wearable device to track their activity. The goal was to see if t…

This study tested whether a 12-week home exercise program using mobile technology, alone or combined with acupressure or mindfulness, could reduce fatigue in cancer survivors. 110 adults who had completed cancer treatment or were on immunotherapy took part. The goal was to see if…

This study watched 91 adults who had robotic surgery to remove part of the pancreas. Researchers measured how long people stayed in the hospital and how quickly they recovered. The goal was to learn more about recovery after this type of surgery.

This study looked at how radiation therapy changes the immune response in people with stage I non-small cell lung cancer. Researchers took small samples of the tumor before and after radiation to see if the treatment helps the immune system recognize and attack cancer cells. Six …

This study examined tissue samples from 49 adults with sinonasal cancer (a rare cancer of the nose and sinuses) to see if high-risk HPV was present. Researchers also looked at how tobacco, alcohol, and other behaviors might affect risk, especially differences between genders and …

This study collected blood and urine samples from 61 men with prostate cancer and healthy volunteers. Researchers looked for cancer DNA in these samples to find better ways to detect and track prostate cancer without invasive procedures. The goal is to improve future diagnosis an…

This study looked at 126 adults aged 60 and older who had a bone marrow transplant for blood cancers like leukemia or lymphoma. Researchers measured physical and mental traits—like strength, memory, mood, and stress—to see which factors help people recover better. The goal was to…

This study looked at whether asking cancer patients to report their own symptoms during radiation treatment helps doctors notice and manage side effects better. 104 adults with lung, esophageal, or other gastrointestinal cancers took part. Doctors reviewed patient-reported sympto…

This early-phase study looked at whether giving a single, short course of the drug flutamide can create DNA breaks in prostate cancer cells. The 25 participants were already receiving standard hormone therapy and brachytherapy. The goal was to see if this approach could make canc…