Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins

This study tested whether adding two immunotherapy drugs (nivolumab and BMS-813160) with or without a cancer vaccine (GVAX) could help control locally advanced pancreatic cancer after standard chemotherapy and radiation. Researchers enrolled 46 patients to check if this combinati…

This study tested whether a combination of a pancreatic cancer vaccine, an immunotherapy drug (pembrolizumab), and precise, high-dose radiation could help control locally advanced pancreatic cancer. It involved 58 patients whose cancer had not spread to distant organs but could n…

This early study tested whether adding a single dose of the drug flutamide to standard prostate cancer treatment (hormone therapy plus radiation seeds) causes DNA damage in cancer cells. Researchers enrolled 25 men with prostate cancer who were already scheduled to receive standa…

This study tested if adding a newer hormone therapy drug called enzalutamide to standard radiation treatment could better control prostate cancer that returns after surgery. It involved 86 men whose cancer had come back, as shown by a rising PSA blood test, but had not spread els…

This study tested whether the immunotherapy drug nivolumab could control prostate cancer recurrence without using hormone-blocking treatments. It involved 8 men whose prostate cancer returned after initial treatment and who had specific genetic markers in their tumors. Researcher…

This study tested whether combining two drugs—copanlisib and nivolumab—could help control advanced cancers that had stopped responding to standard treatments. It focused on a specific type of colorectal cancer (called MSS) that is often resistant to immunotherapy. The main goals …

This study tested a less intense bone marrow transplant for people with serious blood cancers who did not have a perfectly matched donor available. It used donors who were not close relatives or were only a partial match, combined with specific immune-suppressing drugs after the …

This small, early-stage study tested the safety of an experimental drug called flotetuzumab. It was given to a few adults with a type of blood cancer (AML) that had come back after they received a bone marrow transplant. The main goal was to see if the drug was safe and to find t…

This small, early-phase study tested whether giving two immunotherapy drugs (nivolumab and ipilimumab) before standard surgery or other treatments was safe and feasible for people with a rare, aggressive type of nerve tumor. The trial involved 13 participants with these tumors, o…

This study tested if taking a targeted pill called pemigatinib for 4-6 weeks could shrink or eliminate recurrent, non-invasive bladder tumors before standard surgery. It involved 30 patients with a history of low- or intermediate-risk tumors that had come back. The main goal was …

This study tested whether adding two drugs that can modify how genes work (epigenetic modulators) could help a type of immunotherapy (MK-3475) work better for people with a hard-to-treat form of advanced colorectal cancer. It involved 27 adults whose cancer had progressed despite…

This study tested a shorter, more intense radiation schedule combined with temporary hormone therapy for men with intermediate-risk prostate cancer. Forty-five participants received five radiation treatments over about ten days, along with four months of medication to lower testo…

This study tested whether adding two immunotherapy drugs (durvalumab and SNDX-6532) after a standard liver-directed treatment could help control a hard-to-treat liver cancer. It involved 5 patients whose cancer could not be surgically removed. The main goals were to see if the tr…

This study tested whether adding a bone-targeting radioactive drug (Radium-223) to precise, high-dose radiation (SABR) works better than radiation alone for men whose prostate cancer has spread to a few spots, including at least one in bone. The goal was to see if this combined a…

This study tested a shorter, more intense radiation schedule for men with early-stage prostate cancer. The goal was to see if giving fewer, larger daily doses was as effective as standard treatment while carefully tracking side effects and quality of life. It involved 91 men with…

This study tested a new approach for men whose prostate cancer has spread and stopped responding to standard hormone-blocking treatments. Researchers gave participants a high-dose oral testosterone pill in a one-week-on, one-week-off cycle for three months to see if it could shri…

This early-stage study tested the safety of a vaccine called TA-CIN in patients who had recently finished treatment for HPV16 cervical cancer and were currently cancer-free. The goal was to see if the vaccine could safely trigger an immune response to help prevent the cancer from…

This study tested a 12-week home exercise program guided by a smartphone app to help cancer survivors manage fatigue. Researchers also explored if adding simple techniques like applying pressure to specific points on the ear or a brief daily mindfulness exercise could boost the b…

This study tested a new approach to managing side effects during cancer radiation treatment. It involved 104 patients with lung or gastrointestinal cancers. The goal was to see if having patients directly report their symptoms to their doctors each week led to better detection an…

This study tested a home exercise program for cancer survivors who also have diabetes or high blood pressure. Participants used a wearable device and phone app to track their activity and get feedback while choosing from different exercise options like walking or yoga. The main g…

This completed study aimed to understand how human papillomavirus (HPV) contributes to cancers in the nose and sinus area. Researchers analyzed tumor samples and blood from 49 people with sinonasal cancer, comparing them to healthy controls. They examined how factors like tobacco…

This study observed 91 adults who chose to have robotic surgery to remove pancreatic tumors. Researchers tracked how long patients stayed in the hospital, their recovery time, and any complications after surgery. The goal was to gather detailed information on patient outcomes fro…

This study collected blood and urine samples from men with prostate cancer and healthy volunteers. Researchers analyzed the samples to look for genetic differences between cancer cells and normal cells. The goal was to develop a better, non-invasive test to detect prostate cancer…

This small, completed pilot study aimed to understand how a precise, high-dose radiation treatment for early-stage lung cancer might activate the patient's own immune system. Researchers took tiny tumor samples from six patients before and after radiation to see if the treatment …

This study aimed to identify what helps older adults recover well after a bone marrow transplant for blood cancers like leukemia and lymphoma. Researchers measured physical ability, mental health, stress hormones, and other factors in 126 patients aged 60 and older before and aft…