Experimental combo for bile duct cancer shows promise in tiny trial
NCT ID NCT04301778
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 study tested a combination of two drugs, durvalumab and SNDX-6352, in 5 people with advanced bile duct cancer that had not spread beyond the liver. Participants first received standard chemo or radiation therapy directly into the liver, then the drug combination. The goal was to see if the treatment could shrink tumors and to check for side effects. Because only 5 people took part, the results are very preliminary.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- durvalumab and SNDX-6352 (two drugs given by IV infusion)
- What this could lead to
- If it works, this combination could offer a new treatment option for people with advanced bile duct cancer that cannot be removed by surgery.
- What could go wrong
- This was a very small, early-phase trial with only 5 participants, so results may not apply to a larger group. The drugs can cause serious side effects, and the study is already completed without reported outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland, 21231, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Radiation beads plus immunotherapy: a new hope for inoperable bile duct cancer?