Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins

This trial is testing a modified bone marrow transplant procedure designed to cure patients with rare, inherited disorders where the immune system or bone marrow doesn't work properly. The approach uses a less intense pre-transplant treatment and a specific drug after the transpl…

This study is testing a combination of two drugs, enfortumab vedotin and pembrolizumab, for patients with high-grade cancer in their kidney or ureter who are not candidates for or refuse the standard surgery to remove the organ. The goal is to see if this drug treatment can contr…

This study is testing a new treatment sequence for men whose advanced prostate cancer has progressed despite standard hormone therapy. The approach cycles through three drugs—DFMO, high-dose testosterone, and enzalutamide—over 119-day periods, aiming to control cancer growth and …

This study is testing a new approach for men with advanced prostate cancer that has spread. Researchers want to see if giving cycles of very high testosterone followed by a drug that blocks testosterone (darolutamide) can control the cancer longer and cause fewer side effects tha…

This study is for people with advanced HPV-related head and neck cancer. It tests whether starting with immunotherapy (with or without chemo) can allow doctors to use less intense surgery or radiation later, while still aiming for a cure. The main goals are to see if this approac…

This study is testing a bone marrow transplant from a partially matched family donor (like a parent or sibling) for patients with advanced solid tumors that have not responded to other treatments. The goal is to use the donor's immune cells to fight the cancer while using a less …

This study is testing whether adding one or two common medications (dexamethasone and metronidazole) to a standard prostate cancer drug (abiraterone) can help overcome resistance that sometimes develops. It is for men whose metastatic prostate cancer has stopped responding to abi…

This study is testing whether adding an immunotherapy drug called retifanlimab to standard glioblastoma treatment improves outcomes. The trial will enroll 50 adults newly diagnosed with this aggressive brain cancer to evaluate safety and survival. Researchers want to see if combi…

This early-stage study is testing a new personalized vaccine designed to teach the immune system to attack fibrolamellar hepatocellular carcinoma (FLC), a rare liver cancer. The vaccine is given alongside two immunotherapy drugs (nivolumab and ipilimumab) to boost the body's canc…

This study is testing whether using MRI scans instead of CT scans to guide radiation therapy for gynecologic cancers can reduce side effects and improve treatment accuracy. Researchers at Johns Hopkins will compare how well MRI helps doctors target tumors while sparing healthy or…

This early study is testing if a drug called Darzalex Faspro can safely lower harmful antibodies in patients with blood cancers. Lowering these antibodies may allow patients who are currently ineligible to receive a potentially life-saving stem cell transplant from a donor. The s…

This study is testing whether immunotherapy drugs, given alone or in combination, can help control advanced basal cell carcinoma that has spread or cannot be surgically removed. It will enroll about 57 adults with this type of skin cancer and assign them to different treatment gr…

This study is testing whether immunotherapy drugs (cemiplimab with or without fianlimab) can effectively treat a specific type of colorectal cancer in patients aged 70 and older, or in adults who are poor candidates for surgery. The main goal is to see if the treatment can comple…

This study is testing whether a drug called nivolumab can be safely given after a half-matched bone marrow transplant to help prevent cancer from coming back. It involves children and young adults up to age 50 who have high-risk, recurrent, or hard-to-treat sarcomas and have alre…

This study is testing if a 12-week exercise program can reduce the number of prostate cancer cells found in the bloodstream of men with advanced disease. Researchers at Johns Hopkins will enroll 20 men to follow a personalized exercise plan. The main goal is to see if exercise he…

This study is testing a personalized approach to treat stage 2 or 3 triple negative breast cancer before surgery. It aims to see if an early PET scan after one treatment cycle can predict if the cancer is responding, allowing doctors to adjust the treatment plan. The goal is to m…

This study is testing a new approach for people with advanced head and neck cancer. The goal is to see if giving a combination of chemotherapy and immunotherapy *before* surgery can shrink tumors enough to allow surgeons to perform less extensive operations. This could help prese…

This study is testing a new combination of drugs for people newly diagnosed with metastatic pancreatic cancer. The main goal is to check if the treatment is safe and to see if it can help control the cancer. Researchers will measure how long patients live without their cancer get…

This study is testing if a new drug called enoblituzumab, given for 12 weeks before prostate removal surgery, can help men with high-risk prostate cancer. The goal is to see if this approach helps keep the cancer from coming back better than standard care alone. Researchers will …

This study is testing two different combinations of cancer vaccines and immune-boosting drugs for people with pancreatic cancer that can be removed with surgery. The goal is to see which approach is safer and more effective at helping the immune system fight the cancer, both befo…

This study is testing whether combining two drugs—DRP-104 and durvalumab—is safe and can shrink tumors in people with advanced fibrolamellar hepatocellular carcinoma (FLC), a rare liver cancer. It will enroll about 27 patients aged 12 and older whose cancer has progressed despite…

This early-stage trial is testing whether a personalized cancer vaccine that targets specific mutations in tumors, combined with two immunotherapy drugs, can help control advanced colorectal or pancreatic cancer. The study is for patients whose cancer has spread and who have alre…

This early-stage study is testing a new vaccine called PVX7 in patients with advanced cervical cancer who have already completed their main treatment. The main goals are to see if the vaccine is safe and if it can trigger an immune response against the cancer. Researchers will al…

This study is testing a two-step treatment for men whose prostate cancer has spread and stopped responding to standard hormone-blocking therapies. First, patients receive high-dose testosterone combined with an experimental drug called ZEN-3694. If the cancer progresses, they the…

This early-stage study is testing a new combination treatment for people with advanced non-small cell lung cancer that has a specific genetic change called a KRAS mutation. The treatment combines a personalized vaccine designed to target the cancer's mutation with two existing im…

This study is testing a combination of three drugs (gemcitabine, cisplatin, and pembrolizumab) given before and after surgery for bile duct and gallbladder cancers that can be removed by an operation. The main goals are to see if this approach is safe, if patients can still proce…

This study is testing a new, more precise way to deliver radiation treatment for prostate cancer. It uses advanced imaging to target only the aggressive tumor areas while avoiding healthy parts of the prostate. The goal is to control the cancer effectively while aiming to reduce …

This study tests a combination treatment for men with advanced prostate cancer that has spread to bones and stopped responding to standard hormone therapy. Participants receive monthly testosterone injections along with a targeted radiation drug that goes to bone areas. The goal …

This early-stage study is testing whether immune cells from a patient's relative can help fight advanced cancers caused by HPV16. Relatives are vaccinated to boost their immune cells, which are then given to the cancer patient. Researchers are primarily checking if this approach …

This study is testing whether two drugs, Senaparib and Temozolomide, work together to shrink tumors in women with recurrent clear cell or endometrioid ovarian, fallopian tube, or primary peritoneal cancers that have a specific genetic change called an ARID1A mutation. The trial i…

This study is testing whether giving two immunotherapy drugs (pembrolizumab and IO102-103) before surgery is safe and effective for people with head and neck cancer that can be removed by surgery. Researchers will give the drugs to 30 participants and closely monitor side effects…

This study is testing a new two-drug immunotherapy combination for people with advanced cancers that have a specific genetic feature (MSI-H) and have stopped responding to a prior type of immunotherapy. It aims to see if this new combination can shrink tumors and is safe for pati…

This early-stage study is testing whether a personalized vaccine, made from a patient's own tumor mutations, can boost the immune system to fight advanced bile duct cancer when given with two immunotherapy drugs. The main goals are to check if the combination is safe and if it tr…

This study is testing whether a combination of low-dose chemotherapy drugs followed by two maintenance medications can help control advanced pancreatic cancer that has spread. The trial is for adults with newly diagnosed metastatic pancreatic cancer who haven't received any prior…

This early-stage study is testing a new vaccine designed to prevent pancreatic cancer in people at high genetic risk. The vaccine aims to train the immune system to attack cells with a specific cancer-linked mutation. Researchers will enroll 37 participants to check if the vaccin…

This early-stage study is testing a new vaccine designed to prevent or delay the cancer from becoming resistant to current targeted drugs in patients with advanced ALK-positive lung cancer. The vaccine aims to train the immune system to attack the cancer. Researchers will check i…

This study aims to find better ways to measure how a rare bone cancer called chordoma responds to radiation treatment before surgery. Researchers will follow 40 patients receiving radiation and then surgery, checking their blood for tumor DNA and analyzing detailed scans. The goa…

This study is creating a large registry to track children and young adults receiving radiation therapy for sarcoma or brain tumors. It aims to collect detailed treatment and health data to understand long-term survival and side effects. The goal is to compare outcomes between dif…

This study aims to find out if tiny pieces of tumor DNA (ctDNA) found in blood and spinal fluid can be used to monitor how a brain tumor responds to an experimental drug called plixorafenib. It will enroll 15 adults with a specific BRAF-V600E mutated brain tumor that has returned…

This study aims to improve how doctors use radiation-based cancer drugs. Researchers will use a special type of scan (SPECT) to see exactly where these drugs go in the body and how much radiation they deliver. The goal is to gather information that could help doctors personalize …

This study aims to learn more about a serious complication where breast cancer spreads to the lining of the brain and spinal cord (leptomeningeal disease). Researchers will collect blood and fluid samples from about 30 patients to study the biology of this condition. They will al…

This study is testing whether a simple blood test, called a liquid biopsy, can help doctors choose the best treatment for people with solid tumors. Researchers will check if the blood test can find genetic changes in the cancer and if using this information leads to better outcom…

This study aims to increase the use of a specific genetic test for men with advanced prostate cancer. Researchers will work with both doctors and patients at Johns Hopkins to understand and overcome the reasons why this important test is often not ordered. The goal is to ensure m…

This study aims to find out if a high-support patient navigation program helps more people with prostate or kidney cancer join clinical trials compared to a low-support program. Patient navigators help participants overcome barriers to healthcare access. About 90 eligible patient…

This study aims to collect blood and tissue samples from people with head, neck, lung, or gastrointestinal cancers. Researchers will analyze these samples to learn how cancer treatments, especially immunotherapies, affect the body's immune system. The goal is to discover better w…

Due to the subject's lack of conventional treatment options, a treatment plan using X-PACT administered intra-tumorally is proposed. X-PACT (X-ray Psoralen Activated Cancer Therapy) is comprised of a phosphor device (an energy modulation agent), methoxsalen sterile solution (a p…