Double radiation attack aims to blast stubborn thyroid cancer

NCT ID NCT04892303

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests a new way to treat thyroid cancer that has returned or spread. It combines two types of radiation—external beam radiation and radioactive iodine—to deliver a stronger dose to tumors. The goal is to see if this combination is safe and can give a higher radiation dose than either treatment alone. The trial includes adults with a specific type of thyroid cancer that still takes up iodine and cannot be fully removed by surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

external beam radiation plus radioactive iodine (131-I)

What this could lead to

If successful, this approach could allow higher radiation doses to thyroid cancer tumors, potentially improving tumor control without increasing side effects.

What could go wrong

This is an early-phase safety trial with only 48 participants, so effectiveness is not yet proven. There is a risk of serious side effects from the combined radiation.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

differentiated thyroid carcinoma thyroid cancer Thyroid Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • The Johns Hopkins SKCCC

    RECRUITING

    Baltimore, Maryland, 21287, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact

    Contact