Can a simple blood test track brain tumor treatment? new study investigates
NCT ID NCT06610682
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is looking at whether tumor DNA found in blood and spinal fluid can help monitor how well treatment is working in people with a specific type of brain tumor (BRAF-mutant glioma). About 24 participants whose tumors have not responded to prior therapies will receive plixorafenib alone or with retifanlimab. Researchers will collect samples before and during treatment to see if changes in ctDNA levels match tumor shrinkage or growth on MRI scans.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
plixorafenib (a drug taken by mouth) and retifanlimab (an immunotherapy given by infusion)
What this could lead to
If successful, this could help doctors use ctDNA levels to monitor how well treatments are working in BRAF-mutant glioma, potentially guiding future care.
What could go wrong
This is a very early, small study (24 people) focused on measuring ctDNA, not on proving the treatment works. The approach may not reliably track disease or improve outcomes.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Johns Hopkins
RECRUITINGBaltimore, Maryland, 21231, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••