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Scientists hunt for clues to drug resistance in tough colorectal cancer

NCT ID NCT07617610

Recruiting now Knowledge-focused Sponsor: Swiss Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 17, 2026 · Updated 3 times

Summary

This study looks at why a specific type of advanced colorectal cancer (with a BRAF V600E mutation) becomes resistant to standard targeted therapy. Researchers will collect tumor tissue, blood, and stool samples from 30 patients before treatment and when the disease progresses. They will also grow mini-tumors in the lab to test new ways to overcome resistance. The goal is to gather knowledge that could lead to more effective treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Longitudinal translational sampling (tumor tissue, blood, stool) and patient-derived organoids
What this could lead to
If successful, this could reveal why current treatments stop working and point toward new drug combinations to overcome resistance.
What could go wrong
This is an early-stage observational study with only 30 participants, so findings may not apply to all patients. It does not test a new treatment directly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAF V600E MUTATION METASTATIC COLORECTAL CANCER

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Bürgerspital Solothurn

    RECRUITING

    Solothurn, 4500, Switzerland

  • HFR Freiburg - Kantonsspital

    RECRUITING

    Villars-sur-Glâne, 1752, Switzerland

  • HOCH Health Ostschweiz - Kantonsspital St. Gallen

    RECRUITING

    Sankt Gallen, 9007, Switzerland

  • Inselspital Bern

    RECRUITING

    Bern, 3010, Switzerland

  • Kantonsspital Aarau

    RECRUITING

    Aarau, CH-5000, Switzerland

  • Kantonsspital Baden

    RECRUITING

    Baden, 5404, Switzerland

  • Kantonsspital Graubünden

    RECRUITING

    Chur, 7000, Switzerland

  • Kantonsspital Winterthur

    RECRUITING

    Winterthur, 8004, Switzerland

  • Luzerner Kantonsspital

    RECRUITING

    Lucerne, 6004, Switzerland

  • Spitalzentrum Biel - MEDIN La Tour

    RECRUITING

    Biel, 2502, Switzerland

  • St. Claraspital

    RECRUITING

    Basel, 4058, Switzerland

  • Universitaetsspital Basel

    RECRUITING

    Basel, CH-4031, Switzerland

  • Universitätsspital Zürich USZ

    RECRUITING

    Zurich, 8091, Switzerland

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