Blood biomarkers could replace invasive biopsies for colorectal cancer monitoring
NCT ID NCT07754513
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This study investigates whether tiny particles shed by tumors into the blood, called extracellular vesicles, can serve as a non-invasive biomarker for metastatic colorectal cancer. Researchers will analyze blood samples from 290 patients at different treatment stages to see if these vesicles' RNA and protein signatures can predict treatment response and monitor disease progression. The goal is to develop a simple blood test that could guide personalized treatment decisions without the need for repeated tissue biopsies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Blood sample collection for extracellular vesicle biomarker analysis
- What this could lead to
- If successful, this could lead to a simple blood test to monitor colorectal cancer progression and personalize treatment without invasive biopsies.
- What could go wrong
- This is an observational study, so it won't directly test a treatment. The biomarkers may not prove reliable enough for clinical use, and results may not generalize beyond the specific patient group studied.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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Other studies related to the condition(s) this trial covers.
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